Daniel Hartleb - AG Lercher

Plants interact with fungi for more than 400 million years, as well as bacteria. This interaction, called symbiosis, can be either mutualistic (beneficial for plant and symbiont) or parasitic (pathogenic/lethal for plant and beneficial for symbiont). Mutualistic organisms can provide nutrients and phytohormones, suppress pathogens and help withstand heat, salt and drought. Parasitic symptoms range from chlorosis, yellowing, wilting, stunting to cell death and necrosis.

This project focuses on investigating the interaction of Arabidopsis thaliana root inhabiting bacteria and their host. Reconstruction of metabolic network should reveal differences in the metabolism of growth enhancing bacteria and those which miss this capacity in Arabidopsis thaliana. Of interest are also cases where microbial pathways can only be completed with enzymes or transporters encoded in the plant genome (or vice versa).

Starting date: 01.11.2011 / PhD student

Thesis committee members: Martin Lercher, Laura Rose

Mini Academic CV:

  •  2011:
    • MSc in Computer Science, HHU Düsseldorf: "Orthology and Paralogy in completely sequenced plant genomes"
  • 2009:
    • BSc in Computer Science, HHU Düsseldorf: "Comparative transcriptomic of plants with C3- and C4-metabolism"

Publications:

Hartleb D, Jarre F, Lercher MJ (2016) Improved Metabolic Models for E. coli and Mycoplasma genitalium from GlobalFit, an Algorithm That Simultaneously Matches Growth and Non-Growth Data Sets. PLoS Comput Biol Aug 2;12(8)e1005036 undefineddoi: 10.1371/journal.pcbi.1005036. eCollection 2016.

Photo of Daniel  Hartleb

Daniel Hartleb

Building: 25.02
Floor/Room: O2.38
Phone +49 211 81-13716
Fax +49 211 81-15767
Responsible for the content: E-MailDr. Petra Fackendahl