Analysis of subcellular organization within the iron uptake regulation in plants
My PhD project aims to investigate the molecular mechanisms regulating the iron deficiency response in Arabidopsis. Iron is an essential micronutrient for both humans and plants. However, iron deficiency as well as iron excess negatively affect plant's vitality. Therefore, iron uptake and distribution inside the plant must be strictly regulated. During my PhD, I will elucidate the importance of the subcellular/subnuclear organization and protein-proteins interactions of master regulators of iron uptake for finetuning their activity in response to the plant’s needs and environmental cues.
Starting date: 03.06.2019 / Associated Doctoral Researcher
Thesis committee members: Prof. Dr. Petra Bauer, PD Dr. Yvonne Stahl, Dr. Tzvetina Brumbarova
Gratz R, Brumbarova T, Ivanov R, Trofimov K, Tünnermann L, Ochoa‐Fernandez R, Blomeier T, Meiser J, Weidtkamp‐Peters S, Zurbriggen MD, Bauer P (2020) Phospho‐mutant activity assays provide evidence for alternative phospho‐regulation pathways of the transcription factor FER‐LIKE IRON DEFICIENCY‐INDUCED TRANSCRIPTION FACTOR. New Phytol. doi: 10.1111/nph.16168
Trofimov K, Ivanov R, Eutebach M, Acaroglu B, Mohr I, Bauer P, Brumbarova T (2019) Mobility and localization of the iron deficiency-induced transcription factor bHLH039 change in the presence of FIT. Plant Direct. doi: 10.1002/pld3.190
Gratz R, Manishankar P, Ivanov R, Köster P, Mohr I, Trofimov K, Steinhorst L, Meiser J, Mai H-J, Drerup M, Arendt S, Holtkamp M, Karst U, Kudla J, Bauer P, Brumbarova T (2019) CIPK11-Dependent Phosphorylation Modulates FIT Transcription Factor Activity, Promoting Arabidopsis Iron Acquisition in Response to Calcium Signaling. Dev Cell. doi: 10.1016/j.devcel.2019.01.006