Marc-Sven Röll - AG Weber

The Calvin-Benson-Bassham cycle (CBBC), also known as the reductive pentose phosphate cycle, is the most relevant carbon fixating pathway on earth. Although under selective pressure for millions of years the CBBC represents certain inefficiencies in terms of energy usage, enzyme kinetics and abundance. Especially the CO2-fixing enzyme Ribulose-1,5-bisphosphate-carboxylase/-oxygenase is restricted by its slow turnover rate and its oxygenase side reaction. Rubisco oxygenase reaction and following photorespiration diminishes plant carbon efficiency causing agricultural yield loses of up to 36 %.

The mitochondrial multi-enzyme glycine decarboxylase contributes to two important metabolic pathways - photorespiration in all photosynthetic organs and one-carbon metabolism in all biosynthetic active tissues. In plants the provision of one-carbon compounds is highly dependent on glycine decarboxylase activity, resulting in a persistent loss of CO2 and energy-consuming nitrogen reassimilation, limiting plant overall productivity.

Within this project we are investigating alternative routes for the provision of one-carbon compounds using synthetic pathways to improve plant carbon efficiency. Further we are establishing metabolomic tools for the detection of formate to clarify natural sources of formate production in plant metabolism. 

Starting date: 01.01.2017 / PhD student

Thesis committee members: Andreas Weber, Matias Zurbriggen, Wolf Frommer

Mini Academic CV:

  •  2014

    • Bachelor of Science (B. Sc.) Biology Heinrich-Heine University Düsseldorf

      Studies of the hypothetical cryptochrome CmPHR3 in the model red algae Cyanidischizon merolae

  • 2016

    • Master of Science (M. Sc.) Biology, Heinrich Heine University Düsseldorf
      Thesis: Calcium regulated adenine nucleotide transport in plants under stress conditions


Roell MS, Kuhnert F, Zamani-Nour S, Weber APM (2017) In Vitro Analysis of Metabolite Transport Proteins. Methods Mol Biol. 1653:83-96

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Marc-Sven Röll M.Sc.

Verantwortlich für den Inhalt: E-Mail sendenDr. Petra Fackendahl